Microcirculatory, mitochondrial, and histological changes following cerebral ischemia in swine
نویسندگان
چکیده
منابع مشابه
Mitochondrial dynamics following global cerebral ischemia
Global brain ischemia/reperfusion induces neuronal damage in vulnerable brain regions, leading to mitochondrial dysfunction and subsequent neuronal death. Induction of neuronal death is mediated by release of cytochrome c (cyt c) from the mitochondria though a well-characterized increase in outer mitochondrial membrane permeability. However, for cyt c to be released it is first necessary for cy...
متن کاملReperfusion Promotes Mitochondrial Dysfunction following Focal Cerebral Ischemia in Rats
BACKGROUND AND PURPOSE Mitochondrial dysfunction has been implicated in the cell death observed after cerebral ischemia, and several mechanisms for this dysfunction have been proposed. Reperfusion after transient cerebral ischemia may cause continued and even more severe damage to the brain. Many lines of evidence have shown that mitochondria suffer severe damage in response to ischemic injury....
متن کاملReperfusion Promotes Mitochondrial Biogenesis following Focal Cerebral Ischemia in Rats
BACKGROUND AND PURPOSE Reperfusion after transient cerebral ischemia causes severe damage to mitochondria; however, little is known regarding the continuous change in mitochondrial biogenesis during reperfusion. Mitochondrial biogenesis causes an increase in the individual mitochondrial mass of neurons and maintains their aerobic set-point in the face of declining function. The aim of this stud...
متن کاملMicrocirculatory obstruction in focal cerebral ischemia: albumin and erythrocyte transit.
The objectives were to study plasma and erythrocyte flow in an area of acute focal cerebral ischemia and define their relationship to developing microcirculatory obstruction as determined by morphological techniques. Eighteen adult cats, anesthetized with ketamine hydrochloride, had right middle cerebral artery (MCA) occlusion. Plasma flow was determined by measuring the transit of Iodine-131 (...
متن کاملNeuroprotective Effects of Chrysin Mediated by Estrogenic Receptors Following Cerebral Ischemia and Reperfusion in Male Rats
Introduction: Ischemic stroke is one of the leading causes of morbidity and mortality worldwide. Neuroprotective strategies were reported to attenuate cognitive deficits after ischemic incidents. Here we studied the neuroprotective potential of chrysin in a rat model of cerebral Ischemia/Reperfusion (I/R) in the presence or absence of Estrogen Receptors (ERs). Methods: Adult male Wistar rats w...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2014
ISSN: 1471-2202
DOI: 10.1186/1471-2202-15-2